When Prohibition was introduced, I hoped that it would be widely supported by public opinion and the day would soon come when the evil effects of alcohol would be recognized. I have slowly and reluctantly come to believe that this has not been the result. Instead, drinking has generally increased; the speakeasy has replaced the saloon; a vast army of lawbreakers has appeared; many of our best citizens have openly ignored Prohibition; respect for the law has been greatly lessened; and crime has increased to a level never seen before.”

However, when it came to marijuana and hemp prohibition, Rockefeller took a different stance. He was a known supporter of hemp prohibition along with Harry J. Anslinger, the United States First "drug czar" and William Randolph Hearst, well known media mogul. As to be expected, Hearst sympathized with the drug czar in his war against marijuana. Hearst's paper empire, which included hundreds of acres of timber forests, was threatened by the renewable resource of hemp that could be re-grown yearly, unlike Hearst's timber. In his newspapers, Hearst published many of Anslinger’s fabricated stories, aiding the anti-marijuana movement that eventually led to its prohibition in the 1937 Marihuana Tax Act (Wikipedia). Rockefeller had his interests in oil, and after founding Standard Oil in 1870, soared to become the first U.S. dollar billionaire, and Standard Oil was even convicted of monopolistic practices and broken up in 1911. There seems no way that hemp could have had a chance when the media, the government, and the oil industry were swiftly making little room for hemp to survive.